Endocrine Abstracts

Approximately 90% of ovarian cancers are derived from ovarian surface epithelial (OSE) cells and are believed to result from repeated episodes of ovulation-associated injury and repair. A knowledge of the control of OSE cell survival is therefore of major interest regarding our understanding of ovarian cancers. We have previously demonstrated that CREB protein is activated in OSE cells around pre-ovulatory follicles and suggested that this activation may play a role to promote...